The Impact of Hypertension and Metabolic Syndrome on Nitrosative Stress and Glutathione Metabolism in Patients with Morbid Obesity.
Barbara ChoromańskaPiotr MyśliwiecMagdalena ŁubaPiotr WojskowiczHanna MyśliwiecKatarzyna ChoromańskaJacek DadanAnna ZalewskaMaciejczyk MateuszPublished in: Oxidative medicine and cellular longevity (2020)
In this pathbreaking study, we evaluated nitrosative stress in morbidly obese patients with and without metabolic syndrome. 62 women with class 3 obesity (BMI > 40 kg/m2) were divided into three subgroups: obese patients (OB), obese patients with hypertension (OB+HYP), and obese patients with metabolic syndrome (OB+MS). In comparison to the lean patients, OB had increased levels of serum myeloperoxidase (MPO), plasma nitric oxide (NO), S-nitrosothiols, and peroxynitrite (ONOO-), as well as nitrotyrosine, while oxidized glutathione (GSSG) rose only in OB+HYP group. Interestingly, ONOO- was significantly higher in OB+HYP and OB+MS as compared to OB group, while MPO only in OB+MS group. OB+MS had greater nitrotyrosine and S-nitrosothiol values than OB+HYP. Moreover, peroxynitrite could differentiate OB from OB+HYP and OB+MS (AUC 0.9292; p < 0.0001; 87.5% sensitivity, 90% specificity) as well as between OB and OB+MS group (AUC 0.9125; p < 0.0001; 81.25% sensitivity, 83.33%). In conclusion, we showed that MPO activity, NO formation, and nitrosative damage to proteins parallel the progression of metabolic disturbances of obesity. Evaluation of ONOO- concentrations may help predict the development of hypertension and metabolic syndrome in patients with morbid obesity; however, longer-term studies are required for larger numbers of patients.
Keyphrases
- metabolic syndrome
- obese patients
- insulin resistance
- weight loss
- mass spectrometry
- multiple sclerosis
- type diabetes
- ms ms
- nitric oxide
- blood pressure
- adipose tissue
- uric acid
- end stage renal disease
- chronic kidney disease
- newly diagnosed
- oxidative stress
- body mass index
- roux en y gastric bypass
- high fat diet induced
- cardiovascular risk factors
- cardiovascular disease
- body composition
- physical activity
- gestational age