Pirfenidone prevents esophageal stricture by inhibiting nucleotide binding oligomerization domain like receptor protein 3 inflammasome activation.
Shinji HiranoAkira HigashimoriYasuaki NagamiYuji NadataniTetsuya TanigawaMasaki OminamiShusei FukunagaKoji OtaniShuhei HosomiFumio TanakaNoriko KamataKoichi TairaToshio WatanabeYasuhiro FujiwaraPublished in: Journal of gastroenterology and hepatology (2022)
The NLRP3 inflammasome promotes esophageal stricture formation following ulcer healing, and PFD exerts potential prophylactic activity against strictures, possibly via the inhibition of the NLRP3/IL-1β/TGF-β1 axis.