Exosomal microRNAs from PBMCs stimulated with culprit drugs enhanced keratinocyte cell death in Stevens-Johnson syndrome/toxic epidermal necrolysis.

Nithikan SuthumchaiSupranee BuranapraditkunPattarawat ThantiworasitPawinee RerknimitrJongkonnee WongpiyabovornSuparada KhanaraksombatRangsima ReantragoonJettanong Klaewsongkram

Published in: Journal of the European Academy of Dermatology and Venereology : JEADV (2023)

This study illustrated the regulatory functions of exosomal miRNAs in controlling keratinocyte death in SJS/TEN. Exosome inhibitors might have a therapeutic role in SJS/TEN.

Keyphrases

cell death
transcription factor
case report
cell proliferation
cell cycle arrest
drug induced