Obesity of G2e3 Knockout Mice Suggests That Obesity-Associated Variants Near Human G2E3 Decrease G2E3 Activity.
David R PowellDeon D DoreeChristopher M DaCostaKenneth A PlattGwenn H HansenJean-Pierre RevelliZhi-Ming DingJean-Pierre RevelliRobert BrommagePublished in: Diabetes, metabolic syndrome and obesity : targets and therapy (2020)
Significant obesity and glucose intolerance were observed in G2e3, but not Prkd1, KO mice. The conservation of obesity genes between mice and humans strongly suggests that the obesity-associated SNPs located near the human G2E3 and PRKD1 genes are linked to variants that decrease the amount of functional human G2E3.