IL-6 contributes to metastatic switch via the differentiation of monocytic-dendritic progenitors into prometastatic immune cells.

Ksenia Magidey-KleinTim J CooperKsenya KvelerRachelly NormandTongwu ZhangMichael TimanerZiv RavivBrian P JamesRoi GazitZe'ev A RonaiShai Shen-OrrYuval Shaked

Published in: Journal for immunotherapy of cancer (2022)

Our study reveals a new role for tumor-derived IL-6 in hijacking the HSPC differentiation program toward prometastatic MDPs that functionally differentiate into immunosuppressive monocytes to support the metastatic switch.

Keyphrases

squamous cell carcinoma
small cell lung cancer
quality improvement
dendritic cells
peripheral blood