The novel herbicide icafolin-methyl is a plant-specific inhibitor of tubulin polymerization.

Icafolin-methyl is a novel non-selective herbicide with an established mode of action, but with a superior potency and spectrum, specifically after foliar application. This makes icafolin-methyl fundamentally different from existing tubulin polymerization inhibiting herbicides. It complements the farmers weed control toolbox, particularly with respect to resistance management. © 2024 Society of Chemical Industry.