Lesional Antibody Synthesis and Complement Deposition Associate With De Novo Antineuronal Antibody Synthesis After Spinal Cord Injury.
Jan M SchwabCarmen HaiderMarcel A KoppTobias ZrzavyVerena EndmayrGerda RickenHelmut KubistaThomas HaiderThomas LiebscherTom LübstorfChristian BlexLeonarda Serdani-NeuhausArmin CurtPaolo CinelliGiorgio ScivolettoMichael G FehlingsCaroline MayAnnika GuntermannKatrin MarcusChristian MeiselUlrich DirnaglPeter MartusHarald PrüssPhillip G PopovichHans LassmannRomana HöftbergerPublished in: Neurology(R) neuroimmunology & neuroinflammation (2023)
This study provides immunologic, neurobiological, and neuropathologic proof-of-principle for an antibody-mediated autoimmunity response emerging approximately 3 weeks after SCI in a patient subpopulation with a high demand of neuropathic pain medication. Emerging autoimmunity directed against specific spinal cord and neuronal epitopes suggests the existence of paratraumatic CNS autoimmune syndromes.