FTO up-regulation induced by MYC suppresses tumour progression in Epstein-Barr virus-associated gastric cancer.

Yun-Yun XuTing LiAo ShenXiao-Qiong BaoJin-Fei LinLi-Zhen GuoQi MengDan-Yun RuanQi-Hua ZhangZhi-Xiang Zuo Zhao-Lei Zeng

Published in: Clinical and translational medicine (2023)

Mechanistically, our work uncovered a crucial suppressive role of FTO in EBVaGC metastasis and invasiveness via an m6A-FOS-IGF2BP1/2-dependent manner, suggesting a promising biomarker panel for GC metastatic prediction and therapy.

Keyphrases

epstein barr virus
diffuse large b cell lymphoma
squamous cell carcinoma
small cell lung cancer
signaling pathway
transcription factor
pi k akt
binding protein
mass spectrometry