Identification of Molecular Fragments in Equilibrium with Polysiloxane Ultrasmall Nanoparticles.
Paul RocchiLucie LabiedTristan DoussineauMichel JulienBarbara GiroudEmmanuelle VullietJérôme RandonOlivier TillementAgnès HagègeFrançois LuxPublished in: Nanomaterials (Basel, Switzerland) (2022)
During recent decades, ultrasmall inorganic nanoparticles have attracted considerable interest due to their favorable biodistribution, pharmacokinetics and theranostic properties. In particular, AGuIX nanoparticles made of polysiloxane and gadolinium chelates were successfully translated to the clinics. In an aqueous medium, these nanoparticles are in dynamic equilibrium with polysiloxane fragments due to the hydrolysis of Si-O-Si bonds. Thanks to high-performance liquid chromatography coupled with electrospray ionization mass spectrometry, all these fragments were separated and identified.
Keyphrases
- high performance liquid chromatography
- mass spectrometry
- tandem mass spectrometry
- primary care
- liquid chromatography
- molecular dynamics
- solid phase extraction
- molecular dynamics simulations
- high resolution
- walled carbon nanotubes
- photodynamic therapy
- room temperature
- magnetic resonance imaging
- gas chromatography
- magnetic resonance
- fluorescence imaging
- capillary electrophoresis
- iron oxide nanoparticles