Sleep Slow Oscillation-Spindle Coupling Precedes Spindle-Ripple Coupling During Development.

Results indicate a protracted development of synchronized thalamocortical processing specifically in frontocortical networks (i.e., frontal SO-spindle coupling). However, synchronization within thalamocortical networks generally precedes synchronization of thalamocortical with hippocampal processing as reflected by the delayed occurrence of spindle-ripple phase-coupling.