Ethanol disrupts hepatocellular lipophagy by altering Rab5-centric LD-lysosome trafficking.
Micah B SchottCody N RozeveldSaumya BhattBridget CrossmanEugene W KruegerShaun G WellerKaruna RasineniCarol A CaseyMark A McNivenPublished in: Hepatology communications (2024)
These findings support the novel premise of an early endosomal/multivesicular body intermediate compartment on the LD surface that provides a "docking" site for lysosomal trafficking, not unlike the process that occurs during the hepatocellular degradation of endocytosed ligands that is also known to be compromised by EtOH exposure.