Association of ADH1B rs1229984, ADH1C rs698, and ALDH2 rs671 with Alcohol abuse and Alcoholic Cirrhosis in People Living in Northeast Vietnam.
Yen Thi Thu HoangYen Thi NguyenLan Thi VuHuong Thi Thu BuiQuang Viet NguyenNhung Phuong VuTon Dang NguyenNguyen Hai HaPublished in: Asian Pacific journal of cancer prevention : APJCP (2023)
The ALDH2*1 allele was found as a risk factor for alcohol abuse and ALC, and combined genotypes of ADH1B rs1229984, ADH1C rs698, and ALDH2 rs671 with non-acetaldehyde accumulation increase ALC risk. In contrast, ALDH2*2 and the genotype combinations related to high acetaldehyde accumulation were protective factors against alcohol abuse and ALC.