Epigenomic mapping in B-cell acute lymphoblastic leukemia identifies transcriptional regulators and noncoding variants promoting distinct chromatin architectures.

Kelly R Barnett Robert Jackson MobleyJonathan D DiedrichBrennan P BergeronKashi Raj BhattaraiWenjian YangKristine R CrewsChristopher S ManringElias JabbourElisabeth PaiettaMark R LitzowSteven M KornblauWendy StockHiroto InabaSima JehaChing-Hon PuiCharles G MullighanMary V RellingJun J YangWilliam E EvansDaniel Savic

Published in: bioRxiv : the preprint server for biology (2023)

-regulatory rewiring in B-ALL Subtype-specific accessible chromatin signatures representing 20% of all B-ALL sitesRole for distinct TFs in promoting subtype-specific chromatin architecturesThousands of inherited genetic variants identified impacting chromatin state.

Keyphrases

transcription factor
genome wide
gene expression
dna damage
acute lymphoblastic leukemia
copy number
dna methylation
allogeneic hematopoietic stem cell transplantation
acute myeloid leukemia
high density
mass spectrometry