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Boron-Assisted Selective Citrulline Modification under Mild Conditions.

Hailong ZhaoAidong ShanYunshi LiangHaiting WuYiting HeHuihong ChenJiaxin ZengJiangyong GuJian-Ping SongHong QiuJing Zhang
Published in: Organic letters (2022)
Protein citrullination is one type of protein post-translational modification. Previous methods entail the use of a strongly acidic condition (pH <1), which impedes its exploration under physiological and pathological conditions. Here, we developed a biocompatible method based on o -boron-assisted citrulline modification. We demonstrated that this method enables selective and mainly irreversible modification of citrulline residues under neutral conditions. We expect that it will provide a valuable tool for the study of protein citrullination.
Keyphrases
  • protein protein
  • amino acid
  • ionic liquid
  • drug delivery