Azithromycin resistance in Shiga-toxin Producing Escherichia coli in France between 2004 and 2020 and detection of mef(C)-mph(G) genes.

Etienne BizotAurélie CointePhilippe BidetPatricia Mariani-KurkdjianClaire Amaris HobsonCéline CourrouxSandrine LiguoriAntoine Bridier-NahmiasMélanie MagnanManel MerimècheFrançois CamélénaBéatrice BerçotFrançois-Xavier WeillSophie LefèvreStéphane BonacorsiAndre Birgy

Published in: Antimicrobial agents and chemotherapy (2021)

We described and characterized Shiga-toxin-producing Escherichia coli (STEC) strains with high levels of resistance to azithromycin isolated in France, between 2004 and 2020. Nine of 1715 (0.52%) STEC strains were resistant to azithromycin, with an increase since 2017. One isolate carried a plasmid-borne mef(C)-mph(G) genes association, described here for the first time in E. coli. Azithromycin resistance, although rare, needs consideration as this treatment may be useful in case of STEC infection.

Keyphrases

escherichia coli
biofilm formation
klebsiella pneumoniae
genome wide
bioinformatics analysis
dna methylation
pseudomonas aeruginosa
transcription factor
loop mediated isothermal amplification
smoking cessation