SLC6A4 5HTTLPR Polymorphism Affects Insulin Secretion in Patients with Polycystic Ovary Syndrome.

Barbara Šenk Katja Goričar Nika Aleksandra Kravos Mojca Jensterle Sever Andrej Janez Vita Dolzan

Published in: International journal of endocrinology (2018)

Serotonin system may play a role in glucose-stimulated insulin secretion in patients with insulin resistance (IR) and decreased insulin sensitivity. Further studies are needed to conclude whether the observed effect is characteristic for PCOS-related metabolic disturbances or for the identified mutation in different high metabolic risk populations.

Keyphrases

insulin resistance
end stage renal disease
polycystic ovary syndrome
ejection fraction
chronic kidney disease
newly diagnosed
type diabetes
peritoneal dialysis
prognostic factors
blood pressure
skeletal muscle