Natural carriage of Streptococcus pneumoniae is associated with increased experimental pneumococcal carriage but reduced conjugate vaccine efficacy in a human challenge model.
Bridgette GalafaTarsizio ChikaondaEvaristar KudowaSimon SichoneLusako SibaleFaith TholeChristopher MkandawireDingase DulaEdna NsombaGodwin TemboMphatso ChapondaAnthony E ChirwaVitumbiko NkhomaClara NgoliwaRaphael Kamng'onaNeema Mtunthama TotoLumbani MakhazaAlfred MuyayaAshleigh HowardTinashe K NyazikaJohn NdaferankhandeLorensio ChimgonekoNdaziona Peter Kwanjo BandaGift ChiwalaJamie RylanceDaniela FerreiraKondwani C JamboBen MortonMarc Yves Romain HenrionStephen B GordonPublished in: The Journal of infectious diseases (2024)
We have shown that PCV13 VE estimate (62%) is robust whether carriage is assessed by culture or qPCR. PCV13 had lower VE in natural carriers compared to those without natural carriage at the inoculation visit.
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