Infantile Inflammatory Myofibroblastic Tumor of Spleen.
Balamurugan ThirunavukkarasuPritam Singha RoyKirti GuptaAravind SekarDeepak BansalPublished in: Fetal and pediatric pathology (2020)
Background: Inflammatory myofibroblastic tumor (IMT) is a mesenchymal neoplasm with unknown etiology and recurrent potential. They are widely reported in children and young adults. Nearly 50% of inflammatory myofibroblastic tumor harbor rearrangement in anaplastic lymphoma kinase (ALK) gene with the majority expressing ALK protein. ALK-negative IMTs harbor alteration in ROS1 gene in a subset of cases. Few reports have shown association of IMT with Epstein-Barr virus (EBV). Case report: We report a case of IMT of the spleen in an 18-month-old infant presenting with abdominal distention and failure to thrive. Workup for ALK-1, ROS1, and EBV small-encoded RNA in-situ hybridization using immunohistochemistry was negative. Conclusions: IMT can arise in an infant spleen.
Keyphrases
- epstein barr virus
- diffuse large b cell lymphoma
- young adults
- advanced non small cell lung cancer
- case report
- oxidative stress
- cell death
- dna damage
- copy number
- stem cells
- reactive oxygen species
- emergency department
- small molecule
- gene expression
- protein kinase
- dna methylation
- genome wide identification
- binding protein
- tyrosine kinase
- electronic health record
- climate change