Ultra-High Field Diffusion MRI Reveals Early Axonal Pathology in Spinal Cord of ALS mice.
Rodolfo Gabriel GattoManish Y AminDaniel DeyoungMatthew HeyThomas H MareciRichard L MaginPublished in: Translational neurodegeneration (2018)
These findings suggest that the combination of ultra-high field diffusion MRI with fluorescent ALS mice reporters is a useful approach to detect and characterize presymptomatic white matter micro-ultrastructural changes and axonal connectivity anomalies in ALS.
Keyphrases
- white matter
- spinal cord injury
- spinal cord
- amyotrophic lateral sclerosis
- contrast enhanced
- magnetic resonance imaging
- high fat diet induced
- high resolution
- diffusion weighted imaging
- neuropathic pain
- computed tomography
- resting state
- magnetic resonance
- functional connectivity
- insulin resistance
- type diabetes
- metabolic syndrome
- living cells