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Novel acute hypersensitivity pneumonitis model induced by airway mycosis and high dose lipopolysaccharide.

Yuying ZengYun ZhangXinyan HuangLizhen SongKatherine PolskyYifan WuFarrah KheradmandYubiao GuoLinda K GreenDavid B CorryJohn M Knight
Published in: Respiratory research (2021)
In contrast to the strongly allergic lung phenotype induced by fungal spores alone, addition of a relatively high dose of LPS abrogates asthma-like features, replacing them with a phenotype more consistent with acute hypersensitivity pneumonitis (HP). These findings extend the already established link between airway mycosis and asthma to HP and describe a robust model for further dissecting the pathophysiology of HP.
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