Novel acute hypersensitivity pneumonitis model induced by airway mycosis and high dose lipopolysaccharide.
Yuying ZengYun ZhangXinyan HuangLizhen SongKatherine PolskyYifan WuFarrah KheradmandYubiao GuoLinda K GreenDavid B CorryJohn M KnightPublished in: Respiratory research (2021)
In contrast to the strongly allergic lung phenotype induced by fungal spores alone, addition of a relatively high dose of LPS abrogates asthma-like features, replacing them with a phenotype more consistent with acute hypersensitivity pneumonitis (HP). These findings extend the already established link between airway mycosis and asthma to HP and describe a robust model for further dissecting the pathophysiology of HP.
Keyphrases
- high dose
- drug induced
- liver failure
- chronic obstructive pulmonary disease
- allergic rhinitis
- low dose
- stem cell transplantation
- respiratory failure
- lung function
- inflammatory response
- aortic dissection
- magnetic resonance
- interstitial lung disease
- hepatitis b virus
- intensive care unit
- lps induced
- computed tomography
- magnetic resonance imaging
- immune response
- systemic sclerosis