Structural and functional dissection of the Pacinian corpuscle reveals an active role of the inner core in touch detection.

Luke H ZiolkowskiYury A NikolaevAkitoshi ChikamotoMai OdaViktor V FeketaDavid Monedero-AlonsoSerafima A ArdashevaSamuel S BaeC Shan XuSong PangElena O GrachevaSviatoslav N Bagriantsev

Published in: bioRxiv : the preprint server for biology (2024)

eFIB-SEM reveals detailed 3D architecture of the entire Pacinian (Herbst) corpuscleInner, not outer core mediates rapid adaptation and frequency tuningAfferent terminal detects touch via fast-inactivating ion channelsMechanosensitive lamellar Schwann cells tune afferent terminal sensitivity to touch.

Keyphrases

loop mediated isothermal amplification
induced apoptosis
cell cycle arrest
label free
cell death