A novel population of extracellular vesicles smaller than exosomes promotes cell proliferation.

Sang-Soo LeeJong-Hoon WonGippeum J LimJeongran HanJi Youn LeeKyung-Ok ChoYoung-Kyung Bae

Published in: Cell communication and signaling : CCS (2019)

Our study identifies a novel population of EVs present in the P200 fraction. This EV population is distinguished from exosomes in size, protein contents, and biogenesis pathway. Furthermore, exosomes promote their own production whereas the P200 vesicles support cell proliferation. In sum, we report a new group of EVs that are distinct physically, biologically and functionally from exosomes.

Keyphrases

cell proliferation
mesenchymal stem cells
stem cells
cell cycle
genome wide
gene expression
small molecule
signaling pathway
protein protein