SPARC Stabilizes ApoE to Induce Cholesterol-Dependent Invasion and Sorafenib Resistance in Hepatocellular Carcinoma.

Shan Wan Quan-Yao He Yun Yang Feng Liu Xue Zhang Xin Guo Hui Niu Yi Wang Yi-Xuan Liu Wen-Long Ye Xiu-Ming Li Xue-Mei ZhuanSun Pu Sun Xiao-Shun He Guang Hu Kai Breuhahn Hua Zhao Guo-Qiang Wu Hua Wu

Published in: Cancer research (2024)

Intracellular SPARC boosts cholesterol availability to fuel invasion and drug resistance in hepatocellular carcinoma, providing a rational approach to improve the treatment of advanced liver cancer.

Keyphrases

cell migration
low density lipoprotein
high fat diet
type diabetes
skeletal muscle
metabolic syndrome