A NGS-based Blood Test For the Diagnosis of Invasive HPV-associated Carcinomas with Extensive Viral Genomic Characterization.

Xavier Sastre-GarauMamadou DiopFernando MartinGilles DolivetFrédéric MarchalClaire Charra-BrunaudDidier PeiffertLéa LeufflenBirama DembéléJessica DemangePriscillia TostiJacques ThomasAgnès LerouxJean-Louis MerlinHalimatou Diop-NdiayeJean-Marc CostaJulia SalleronAlexandre Harlé

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)

In patients with carcinoma associated with any HPV genotype, a complete viral genome characterization can be obtained via the analysis of a standard blood sample. This should favor the development of noninvasive diagnostic tests providing the identification of personalized tumor markers.See related commentary by Rostami et al., p. 5158.

Keyphrases

high grade
sars cov
copy number
genome wide
cervical cancer screening
gene expression