Empiric antibiotic therapy in early periprosthetic joint infection: a retrospective cohort study.
Ruben ScholtenPeter M C Klein KlouwenbergJet E H GisolfJob L C van SusanteMatthijs P SomfordPublished in: European journal of orthopaedic surgery & traumatology : orthopedie traumatologie (2021)
Vancomycin combined with ciprofloxacin or a third generation cephalosporin provided the highest antimicrobial coverage of all responsible pathogens identified in early PJI. Empiric treatment of gram-negative treatment can be safely terminated in the absence of gram-negative pathogens after 4 days of culturing in cases without preoperative antibiotic treatment.