Suppression of FOXC1 induces pyroptosis of the coronary artery through activation of JAK2.

Jiayun QiuYahong FuTing TianYan MaoQiang TianLanbo ZhouRui JinLili ZhuangGuoping Zhou

Published in: Atherosclerosis (2024)

We established the FOXC1-JAK2 regulatory pathway and verified its reverse-regulatory function in CAD pyroptosis. Our data emphasizes that FOXC1 is critical for the treatment of pyroptosis-induced injury in patients with CAD.

Keyphrases

nlrp inflammasome
coronary artery
coronary artery disease
transcription factor
diabetic rats
oxidative stress
combination therapy
artificial intelligence
deep learning
data analysis