A facile strategy to realize a single/double photon excitation-dependent photosensitizer for imaging-guided phototherapy against HeLa cancer cells at separate irradiation channels.

Lin KongZe HuangShuai-Shuai ZhangJian SongYu-Yang ZhangXiang-Yang BaiJia-Xiang Yang Lin Li

Published in: Chemical communications (Cambridge, England) (2019)

A novel difluoroboron fluorophore with an electron donor-acceptor conjugated structure was synthesized with 26.5% fluorescence quantum yield, 18 035 GM two-photon absorbing cross-section, and undetectable two-photon fluorescence, resulting in 25% 1O2 quantum yield. The unique optical behavior of CNFBBN enabled one-photon fluorescence imaging and two-photon phototherapy against HeLa cancer cells, irradiated at separate wavelengths.

Keyphrases

energy transfer
fluorescence imaging
living cells
monte carlo
photodynamic therapy
fluorescent probe
high resolution
single molecule
molecular dynamics
quantum dots
signaling pathway
mass spectrometry
high speed
gold nanoparticles
reduced graphene oxide
highly efficient
electron microscopy