Recommendations For a Standardized Approach to Histopathologic Evaluation of Synovial Membrane in Murine Models of Experimental Osteoarthritis.

Alia M ObeidatSung Yeon KimKevin G BurtBaofeng HuJun LiShingo IshiharaRui XiaoRachel E Miller Christopher B Little Anne-Marie Malfait Carla R Scanzello

Published in: bioRxiv : the preprint server for biology (2023)

To allow for a standard evaluation that can be implemented and compared across labs and studies, we recommend using 3 readers to evaluate a minimum set of 3 pathological features at standardized anatomic areas. Pre-defining areas to be scored, and reliability for each pathologic feature should be considered.

Keyphrases

machine learning
rheumatoid arthritis
neoadjuvant chemotherapy
deep learning
knee osteoarthritis
case control
clinical evaluation