HEG1, BAP1, and MTAP are useful in cytologic diagnosis of malignant mesothelioma with effusion.

Kenzo HiroshimaDi WuShinji HamakawaShingo TsuruokaDaisuke OzakiHideki OrikasaMizue HasegawaEitetsu KohYasuo SekineYoko YonemoriKazuki NabeshimaShoutaro TsujiYohei MiyagiKohzoh Imai

Published in: Diagnostic cytopathology (2020)

HEG1 is a good marker for mesothelial differentiation in effusion cytology. HD of CDKN2A is frequently observed in cell blocks from effusions of MMs, and MTAP IHC may act as a surrogate for HD of CDKN2A. Cell block analysis is recommended for effusions of unknown origins with the following methods: IHC with HEG1 and claudin 4 to validate the mesothelial origin, followed by BAP1 and MTAP IHC to confirm malignancy.

Keyphrases

single cell
cell therapy
fine needle aspiration
stem cells
mesenchymal stem cells
bone marrow
endothelial cells