Report from the HarmoSter study: inter-laboratory comparison of LC-MS/MS measurements of corticosterone, 11-deoxycortisol and cortisone.
Flaminia FanelliStephen BruceMarco CantùAnastasia TemchenkoMarco MezzulloJohanna M LindnerMirko PeitzschPierre-Alain BinzMariette T AckermansAnnemieke C HeijboerJody Van den OuwelandDaniel KoepplElena NardiManfred RauhMichael VogeserGraeme EisenhoferUberto PagottoPublished in: Clinical chemistry and laboratory medicine (2022)
Method imprecision was variable. Inter-laboratory performance was reasonably good. However, cases with imprecision and total error above the acceptable limits were apparent for corticosterone and 11-deoxycortisol. Variability did not depend on calibration but apparently on imprecision, accuracy and specificity of individual methods. Tools for improving selectivity and accuracy are required to improve harmonization.