Impaired breakdown of Herwig's epithelial root sheath disturbs tooth root development.
Ju-Kyung JeongTak-Heun KimHwajung ChoiEui-Sic ChoPublished in: Developmental dynamics : an official publication of the American Association of Anatomists (2023)
Our data suggest that Wnt/β-catenin signaling is decreased in HERS for ERM formation during root development. Furthermore, ERM formation is important for further elongation and dentin mineralization of the tooth roots. These findings may provide new insight to understand the contribution of ERM to root formation.