Pumping Iron: Ferritinophagy Promotes Survival and Therapy Resistance in Pancreatic Cancer.
Vaibhav JainRavi K AmaravadiPublished in: Cancer discovery (2022)
Autophagy is an adaptive response to metabolic and therapeutic stress, especially in treatment-refractory cancers such as pancreatic cancer. In this issue of Cancer Discovery, two groups establish ferritinophagy, a selective autophagy program that could become a drug target, as the mechanism that pumps iron into mitochondria via the lysosome, enabling survival and therapy resistance in pancreas cancer. See related article by Santana-Codina et al., p. 2180 (3). See related article by Ravichandran et al., p. 2198 (4).
Keyphrases
- papillary thyroid
- cell death
- squamous cell
- endoplasmic reticulum stress
- signaling pathway
- oxidative stress
- small molecule
- free survival
- childhood cancer
- squamous cell carcinoma
- lymph node metastasis
- high throughput
- emergency department
- stem cells
- young adults
- mesenchymal stem cells
- living cells
- drug induced
- stress induced
- adverse drug
- combination therapy