A Novel Rat Model to Study Postsurgical Pain After Joint Replacement Surgery.

Naoki Aoyama Masashi IzumiToru MorimotoHiroyuki WadaJunpei DanYusuke KasaiYoshinori SatakeKoji AsoMasahiko Ikeuchi

Published in: Journal of pain research (2022)

Our novel JR model presented acute postsurgical pain behavior that was successfully recovered to the baseline level at day 42 after surgery. Difference of the pain manifestation between the JR and JD groups could be supported by the expression of CGRP-IR in DRG neurons. This model is the first step toward understanding detailed mechanisms of post-JR pain.

Keyphrases

chronic pain
pain management
neuropathic pain
minimally invasive
spinal cord injury
intensive care unit
postoperative pain
atrial fibrillation
extracorporeal membrane oxygenation