Tolerogenic properties of liver macrophages in non-alcoholic steatohepatitis.
Lorenzo A OrciMario KreutzfeldtNicolas GoossensLaura Rubbia-BrandtFlorence SlitsKarim HammadVaihere DelauneGraziano OldaniFrancesco NegroSophie ClémentCarmen Gonelle-GispertLéo H BuhlerChristian TosoStéphanie LacottePublished in: Liver international : official journal of the International Association for the Study of the Liver (2020)
Liver macrophages can achieve endotoxin tolerance, but in the chronically inflamed fatty liver, while they acquire an immunomodulatory phenotype, liver macrophages fail to dampen immune-mediated damage. Therefore, loss of tolerogenicity induced by ongoing liver insult may be a mechanism contributing to the worsening of NAFLD.