Characterization and evaluation of the enzymatic activity of tetanus toxin submitted to cobalt-60 gamma radiation.
Giselle Pacífico Sartori DamiãoAndréa da CostaFernanda Lúcio Dos Santos MacariniDouglas Oscar Ceolin MarianoDaniel Carvalho PimentaPatrick Jack SpencerLuiz Henrique da Silva NaliAndrés Jimenez GalisteoPublished in: The journal of venomous animals and toxins including tropical diseases (2021)
Ionizing radiation promoted structural changes in the tetanus toxin such as fragmentation and/or aggregation and attenuation of enzymatic activity as the dose increased, but antigenic recognition of the toxin remained at good levels indicating its possible use as an immunogen. However, studies of enzymatic activity of tetanus toxin irradiated with doses above 8 kGy should be further analyzed.