Atrial myocyte-derived exosomal microRNA contributes to atrial fibrosis in atrial fibrillation.

Hongting HaoSen YanXinbo ZhaoXuejie HanNing FangYun ZhangChenguang DaiWenpeng LiHui YuYunlong GaoDingyu WangQiang GaoYu DuanYue YuanYue Li

Published in: Journal of translational medicine (2022)

Atrial myocyte-derived exosomal miR-210-3p promoted cell proliferation and collagen synthesis by inhibiting GPD1L in atrial fibroblasts. Preventing pathological crosstalk between atrial myocytes and fibroblasts may be a novel target to ameliorate atrial fibrosis in patients with AF.

Keyphrases

atrial fibrillation
left atrial
catheter ablation
oral anticoagulants
left atrial appendage
cell proliferation
direct oral anticoagulants
heart failure
percutaneous coronary intervention
mitral valve
left ventricular
signaling pathway
coronary artery disease
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