Low Prevalence of Nirmatrelvir-Ritonavir Resistance-Associated Mutations in SARS-CoV-2 Lineages From Botswana.

Wonderful Tatenda ChogaOntlametse T BarengNatasha O MorakaDorcas Maruapula Irene GobeNokuthula S NdlovuBoitumelo J L ZuzePatience C MotshosiKedumetse B SeruTeko MatsuruMatshwenyego BoitswareloMogomotsi MatshabaTendani GaolatheMosepele Mosepele Joseph MakhemaTrevor J M TamuraJonathan Z LiRoger L Shapiro Shahin Lockman Simani Gaseitsiwe Sikhulile Moyo

Published in: Open forum infectious diseases (2024)

The frequency of NTV/r RAMs in Botswana was low. Higher rates were observed in Delta VOCs compared to Omicron and Beta VOCs. As NTV/r use expands globally, continuous surveillance for drug-resistant variants is essential, given the RAMs identified in our study.

Keyphrases

drug resistant
sars cov
multidrug resistant
acinetobacter baumannii
risk factors
copy number
antiretroviral therapy
genome wide