Heart Rate Reduction with Ivabradine Prevents Cardiac Rupture after Myocardial Infarction in Mice.
Masataka IkedaTomomi IdeShun FurusawaKosei IshimaruTomonori TadokoroHiroko Deguchi MiyamotoSoichiro IkedaKosuke OkabeAkihito IshikitaKo AbeShouji MatsushimaHiroyuki TsutsuiPublished in: Cardiovascular drugs and therapy (2021)
Our findings suggest that HR reduction with IVA prevents cardiac rupture after MI. This may be particularly effective in MI patients with a high HR who are either unable to adequately tolerate β-blockers or whose HR remains high despite receiving β-blockers.