The role of the aging microenvironment on the fate of PDGFRβ lineage cells in skeletal muscle repair.

Aiping LuChieh TsengPing GuoZhanguo GaoKaitlyn E WhitneyMikhail G KoloninJohnny Huard

Published in: Stem cell research & therapy (2022)

Our data suggest that PDGFRβ lineage cells function as MPCs in young mice, while the same PDGFRβ lineage cells from old mice undergo a fate switch participating in adipose and fibrotic tissue infiltration in aged muscle. The inhibition of fate-switching in PDGFRβ lineage cells may represent a potential approach to prevent fibrosis and fatty infiltration in skeletal muscle during the aging process.

Keyphrases

skeletal muscle
induced apoptosis
cell cycle arrest
single cell
endoplasmic reticulum stress
cell death
systemic sclerosis
signaling pathway
machine learning
risk assessment
climate change
electronic health record
artificial intelligence