Anti-CD20 Therapy Alters the Protein Signature in Experimental Murine AIH, but Not Exclusively towards Regeneration.

Laura Elisa Buitrago-MolinaJanine DywickiFatih NoyanLena SchepergerdesJulia PietrekMaren LieberJerome SchlueMichael P MannsHeiner WedemeyerElmar JaeckelMatthias Hardtke-Wolenski

Published in: Cells (2021)

In conclusion, anti-CD20 therapy did not produce clinically measurable results because it triggered inflammation, as well as regeneration, at the proteomic level. This finding suggests that anti-CD20 is ineffective as a sole treatment for AIH or emAIH.

Keyphrases

stem cells
nk cells
cell therapy
binding protein
protein protein
combination therapy