Haem iron reshapes colonic luminal environment: impact on mucosal homeostasis and microbiome through aldehyde formation.
Océane C B MartinMaïwenn OlierSandrine Ellero-SimatosNathalie NaudJacques DupuyLaurence HucSylviane TachéVanessa GraillotMathilde LevêqueValérie BézirardCécile Héliès-ToussaintFlorence Blas Y EstradaValérie TondereauYannick LippiClaire NayliesLindsey PeyrigaCécile CanletAnne Marie DavilaFrançois BlachierLaurent FerrierElisa Boutet-RobinetFrançoise GuéraudVassilia ThéodorouFabrice H F PierrePublished in: Microbiome (2019)
This integrated approach provides an overview of haem-induced modulations of the main actors in the colonic barrier. All alterations were closely linked to haem-induced lipoperoxidation, which is associated with red meat-induced colorectal cancer risk.