Picraquanines A－C, three new phenolic derivatives from the stems of Picrasma quassioides.
Rui XuDongdong ZhangFangfang ShuZehai LongYiming LiZheng-Tao WangLi YangRui WangPublished in: Natural product research (2020)
Three new phenolic derivatives, picraquanines A-C (1-3), along with 6 known ones 4-9 were obtained from the stems of Picrasma quassioides (D. Don) Benn. The new structures were determined by extensive spectroscopic data analysis, including IR, HRESIMS, 1H-NMR, 13C-NMR, HSQC, HMBC, 1H-1H COSY experiments. The absolute configuration of 1 was determined by comparison of its experimental and calculated ECD spectra. Furthermore, all the compounds were tested for their nitric oxide (NO) inhibitory effects against LPS-stimulated RAW 264.7 cells, however, none of them exhibited inhibitory effects (IC50 >100 μM).[Figure: see text].
Keyphrases
- data analysis
- high resolution
- nitric oxide
- magnetic resonance
- induced apoptosis
- solid state
- cell cycle arrest
- molecular docking
- structure activity relationship
- hydrogen peroxide
- endoplasmic reticulum stress
- smoking cessation
- nitric oxide synthase
- cell death
- anti inflammatory
- signaling pathway
- oxidative stress
- density functional theory
- cell proliferation
- molecular dynamics simulations
- clinical evaluation