Drug-induced liver injury (DILI) ascribed to non-steroidal anti-inflammatory drugs (NSAIDs) in the USA-Update with genetic correlations.

Herbert L Bonkovsky Marwan S GhabrilPaola NicolettiAndrew DellingerRobert J FontanaHuiman BarnhartJiezhun GuAnn K DalyGuruprasad P AithalElizabeth J PhillipsDavid E Kleinernull null

Published in: Liver international : official journal of the International Association for the Study of the Liver (2024)

Despite prevalent use, NSAID-DILI is infrequent in the United States. Diclofenac is the most commonly implicated, and adherence to warnings of risk and close observation are recommended. The increased frequency of HLA-B*35:03 and DRB1*04:03, driven by diclofenac, suggests the importance of immune-mediated responses.

Keyphrases

anti inflammatory drugs
drug induced
genome wide
adverse drug
copy number
emergency department
metabolic syndrome
dna methylation
insulin resistance