Inhibition of multidrug resistance proteins by MK571 restored the erectile function in obese mice through cGMP accumulation.
Mariana Gonçalves de OliveiraGabriela Reolon PassosErick de Toledo de GomesGuilherme Ruiz LeonardiAdriana ZapparoliEdson AntunesFabiola Zakia MónicaPublished in: Andrology (2022)
The MRPs inhibition by MK571 favored the accumulation of cGMP in the smooth muscle cells, thus improving the smooth muscle relaxation and the erectile function in obese mice.