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Network alterations underlying anxiety symptoms in early multiple sclerosis.

Erik EllwardtMuthuraman MuthuramanGabriel Gonzalez-EscamillaVenkata Chaitanya ChirumamillaFelix LuessiStefan BittnerFrauke ZippSergiu GroppaVinzenz Fleischer
Published in: Journal of neuroinflammation (2022)
Anxiety-related prefrontal cortical atrophy in MS leads to a specific network alteration involving structures that resemble known neurobiological anxiety circuits. These findings elucidate the emergence of anxiety as part of the disease pathology and might ultimately enable targeted treatment approaches modulating brain networks in MS.
Keyphrases
  • multiple sclerosis
  • sleep quality
  • mass spectrometry
  • white matter
  • ms ms
  • high resolution
  • depressive symptoms
  • working memory
  • functional connectivity
  • drug delivery
  • blood brain barrier
  • network analysis