TCF7L2 Genetic Variants Do Not Influence Insulin Sensitivity or Secretion Indices in Autoantibody-Positive Individuals at Risk for Type 1 Diabetes.

Maria Jose RedondoMegan V WarnockIngrid M LibmanLaura E BocchinoDavid CuthbertsonSusan GeyerAlberto PuglieseAndrea K SteckCarmella Evans-MolinaDorothy BeckerJay M SosenkoFida Bachanull null

Published in: Diabetes care (2021)

In nondiabetic autoantibody-positive individuals, TCF7L2 SNPs were not related to insulin sensitivity or secretion indices after accounting for BMI z score, age, sex, and ethnicity.

Keyphrases

type diabetes
body mass index
genome wide
cardiovascular disease
glycemic control
gene expression
adipose tissue
dna methylation
skeletal muscle
genome wide association