A post-mortem analysis of tenofovir, lamivudine, efavirenz and fluconazole penetration in female genital tissues.

Fan WangOlivie C NamujuKatelyn A PastickKizito AbdusalaamuUsha MishraLindsey CollinsDavid R BoulwareRobert LukandeDavid B MeyaMelanie R Nicol

Published in: The Journal of antimicrobial chemotherapy (2022)

Penetration of anti-infectives was not homogeneous among the FGT compartments. Approximately 70% of FGT tissues had a TPR of greater than 1 for tenofovir and lamivudine, favouring the prevention of local HIV replication and transmission in the FGT.

Keyphrases

antiretroviral therapy
hiv infected patients
hiv infected
hiv positive
human immunodeficiency virus
hiv aids
gene expression
candida albicans
men who have sex with men