Cancer Risk in a Large Inception Systemic Lupus Erythematosus Cohort: Effects of Demographic Characteristics, Smoking, and Medications.
Sasha BernatskyRosalind Ramsey-GoldmanMurray B UrowitzJohn G HanlyCaroline GordonMichelle A PetriEllen M GinzlerDaniel J WallaceSang-Cheol BaeJuanita Romero-DiazMary Anne DooleyChristine A PeschkenDavid Alan IsenbergAnisur RahmanSusan ManziSøren JacobsenSung Sam LimRonald van VollenhovenOla NivedDiane L KamenCynthia AranowGuillermo Ruiz-IrastorzaJorge Sánchez-GuerreroDafna D GladmanPaul R FortinGraciela S AlarconJoan T MerrillKenneth C KalunianManuel Ramos-CasalsKristjan SteinssonAsad ZomaAnca AskanaseMunther A KhamashtaIan BruceMurat InancAnn Elaine ClarkePublished in: Arthritis care & research (2021)
Smoking is a key modifiable risk factor, especially for lung cancer, in SLE. Immunosuppressive medications were not clearly associated with higher risk except for cyclophosphamide and nonmelanoma skin cancer. Antimalarials were negatively associated with breast cancer and nonmelanoma skin cancer risk. SLE activity was associated positively with hematologic cancer and negatively with nonmelanoma skin cancer. Since the absolute number of cancers was small, additional follow-up will help consolidate these findings.