Sustained maternal antibody and cellular immune responses in pregnant women infected with Zika virus and mother to infant transfer of Zika-specific antibodies.
Ai-Ris Y CollierErica N BorducchiAbishek ChandrashekarEdward MoseleyLauren PeterNicholas S TeodoroJoseph NkololaPeter AbbinkDan H BarouchPublished in: American journal of reproductive immunology (New York, N.Y. : 1989) (2020)
We detected a robust, prolonged maternal humoral immune response to ZIKV during pregnancy and postpartum. We also demonstrated evidence for efficient transplacental antibody transfer from mother to infant at birth, supporting the importance of neonatal passive immunity to ZIKV. Maternal T-cell responses were less consistent among pregnant women infected with ZIKV.