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Evaluating the impact of transient shear stress on platelet activation, adhesion, and aggregation with microfluidic chip technique.

Xuemei GaoTiancong ZhangXiaojing HuangXuanrong HuanYuan Li
Published in: Artificial organs (2023)
Transient high shear stress (46 ms) can effectively activate platelets. Platelet aggregation behavior was different for coated fibrinogen and collagen protein. Stable platelet adhesion at post-stenosis is more dependent on fibrinogen and platelet aggregation is stable on both fibrinogen and collagen. Hematocrit can significantly affect the formation of platelet aggregation.
Keyphrases
  • high throughput
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  • cell migration