Evaluating the impact of transient shear stress on platelet activation, adhesion, and aggregation with microfluidic chip technique.
Xuemei GaoTiancong ZhangXiaojing HuangXuanrong HuanYuan LiPublished in: Artificial organs (2023)
Transient high shear stress (46 ms) can effectively activate platelets. Platelet aggregation behavior was different for coated fibrinogen and collagen protein. Stable platelet adhesion at post-stenosis is more dependent on fibrinogen and platelet aggregation is stable on both fibrinogen and collagen. Hematocrit can significantly affect the formation of platelet aggregation.